Centre for Misfolding Diseases

Publications

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  • Currently displaying 161 - 180 of 2350 publications
Author(s)
Publication title
Journal Name
Publication year
Understanding Biology in the Age of Artificial Intelligence
E Lawrence, A El-Shazly, S Seal, CK Joshi, P Liò, S Singh, A Bender, P Sormanni, M Greenig
(2024)
Fabrication of gradient hydrogels using a thermophoretic approach in microfluidics
A Kosmidis Papadimitriou, SW Chong, Y Shen, OS Lee, TPJ Knowles, LM Grover, D Vigolo
Biofabrication
(2024)
16
(doi: 10.1088/1758-5090/ad2b05)
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions.
S Chia, RL Cataldi, FS Ruggeri, R Limbocker, I Condado-Morales, K Pisani, A Possenti, S Linse, TPJ Knowles, J Habchi, B Mannini, M Vendruscolo
ACS Chem Neurosci
(2024)
15
(doi: 10.1021/acschemneuro.3c00718)
Targeted protein editing with an antibody-based system
M Vendruscolo, O Rimon, J Konc, M Ali, VR Chowdhury, P Sormanni, G Bernardes
(2024)
(doi: 10.21203/rs.3.rs-3947849/v1)
Misfolded protein oligomers: Mechanisms of formation, cytotoxic effects, and pharmacological approaches against protein misfolding diseases
DJ Rinauro, F Chiti, M Vendruscolo, R Limbocker
Molecular Neurodegeneration
(2024)
19
(doi: 10.1186/S13024-023-00651-2)
Large-scale visualisation of α-synuclein oligomers in Parkinson's disease brain tissue
R Andrews, B Fu, C Toomey, J Breiter, J Lachica, R Tian, J Beckwith, L-M Needham, G Chant, C Loiseau, A Deconfin, K Baspin, P Magill, Z Jaunmuktane, O Freeman, BJM Taylor, J Hardy, T Lashley, M Ryten, M Vendruscolo, N Wood, L Weiss, S Gandhi, S Lee
(2024)
(doi: 10.1101/2024.02.17.580698)
Cathepsin B Processing is Required for the in vivo Efficacy of Albumin-Drug Conjugates
B Bernardim, J Conde, T Hakala, JB Becher, M Canzano, AV Vasco, TPJ Knowles, J Cameron, GJL Bernardes
Bioconjugate chemistry
(2024)
35
(doi: 10.1021/acs.bioconjchem.3c00478)
Self-replication of Aβ42 aggregates occurs on small and isolated fibril sites
S Curk, J Krausser, G Meisl, D Frenkel, S Linse, TCT Michaels, TPJ Knowles, A Šarić
Proceedings of the National Academy of Sciences
(2024)
121
(doi: 10.1073/pnas.2220075121)
Modulation of α-synuclein in vitro aggregation kinetics by its alternative splice isoforms.
A Röntgen, Z Toprakcioglu, JE Tomkins, M Vendruscolo
Proceedings of the National Academy of Sciences of the United States of America
(2024)
121
(doi: 10.1073/pnas.2313465121)
Maturation-dependent changes in the size, structure and seeding capacity of Aβ42 amyloid fibrils
A Miller, S Chia, E Klimont, TPJ Knowles, M Vendruscolo, FS Ruggeri
Communications biology
(2024)
7
(doi: 10.1038/s42003-024-05858-7)
Temperature-induced changes in protein interactions control RNA recruitment to G3BP1 condensates
C Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, T Knowles
(2024)
(doi: 10.1101/2024.02.02.578543)
Novel methods to study amyloid oligomers
LO Pascual, EA Andrzejewska, T Pálmadóttir, TP Knowles, S Linse
Biophysical Journal
(2024)
123
(doi: 10.1016/j.bpj.2023.11.331)
Thermodynamics of temperature modulation in biomolecular phase separation
CM Fischer, H Ausserwöger, T Sneideris, D Qian, R Scrutton, S Qamar, P St George-Hyslop, TP Knowles
Biophysical Journal
(2024)
123
(doi: 10.1016/j.bpj.2023.11.2994)
Sequence-Based Drug Design Using Transformers
M Vendruscolo, S Zhang, D Huo, R Horne, Y Qi, SP Ojeda, A Yan
(2024)
(doi: 10.21203/rs.3.rs-3682847/v1)
Molecular chaperones and their role in amyloid formation
MM Schneider, A Bracher, EA Andrzejewska, G Krainer, L-U Lin, R Riek, U Hartl, TPJ Knowles
Biophysical Journal
(2024)
123
(doi: 10.1016/j.bpj.2023.11.1869)
Imaging Aβ aggregation by liquid-phase transmission electron microscopy
G Ing, S Acosta-Gutiérrez, M Vendruscolo, G Battaglia, L Ruiz-Pérez
(2024)
(doi: 10.1101/2024.01.29.577710)
Transient interactions between the fuzzy coat and the cross-β core of brain-derived Aβ42 filaments
M Vendruscolo, M Milanesi, F Brotzakis
(2024)
(doi: 10.21203/rs.3.rs-3847495/v1)
Improving Antibody Humanness Prediction using Patent Data
T Ucar, A Ramon, D Oglic, R Croasdale-Wood, T Diethe, P Sormanni
(2024)
Using Generative Modeling to Endow with Potency Initially Inert Compounds with Good Bioavailability and Low Toxicity
RI Horne, J Wilson-Godber, A González Díaz, ZF Brotzakis, S Seal, RC Gregory, A Possenti, S Chia, M Vendruscolo
Journal of Chemical Information and Modeling
(2024)
64
(doi: 10.1021/acs.jcim.3c01777)
The Alzheimer’s Aβ peptide forms biomolecular condensates that trigger amyloid aggregation
G Šneiderienė, AG Díaz, SD Adhikari, J Wei, T Michaels, T Šneideris, S Linse, M Vendruscolo, K Garai, TPJ Knowles
(2024)
(doi: 10.1101/2024.01.14.575549)
Yusuf Hamied Department of Chemistry
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