Centre for Misfolding Diseases

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  • Currently displaying 1 - 20 of 2350 publications
Author(s)
Publication title
Journal Name
Publication year
Bright sorting yields drug-like anti-amyloid antibodies
B Li, P Sormanni
Trends in Pharmacological Sciences
(2025)
46
(doi: 10.1016/j.tips.2025.05.013)
Global kinetic model of lipid-induced α-synuclein aggregation and its inhibition by small molecules.
A Stevenson, R Staats, AJ Dear, D Voderholzer, JE Dreier, G Meisl, R Guido, TPJ Knowles, C Galvagnion, AK Buell, M Vendruscolo, TCT Michaels
Proceedings of the National Academy of Sciences
(2025)
122
(doi: 10.1073/pnas.2422427122)
On-Chip De Novo Production of mRNA Vaccine in Lipid Nanoparticles
S Zilberzwige-Tal, A Levin, A Ezra, U Elia, G Finkelstein-Zuta, T Kreiser, L Gershon, M Goldsmith, E Kon, Y Navon, O Cohen, TPJ Knowles, D Peer, E Gazit
Small (Weinheim an der Bergstrasse, Germany)
(2025)
(doi: 10.1002/smll.202500114)
Proteostasis signatures in human diseases.
CM Lim, M Vendruscolo
Plos Computational Biology
(2025)
21
(doi: 10.1371/journal.pcbi.1013155)
Patch deconvolution for Fourier light-field microscopy
B Fu, C Jones, D Heraghty, S Yang, C O’Brien-Ball, V Junghans, H Yang, TPJ Knowles, L Weiss, R Fernandes, S Lee
(2025)
(doi: 10.1101/2025.06.13.659385)
DNA Partitioning Modulates Liquid-to-Solid Transitions and the Internal Microstructure of FUS Condensates
D Ilhamsyah, C Luong, S Qamar, PS George-Hyslop, J MacKay, LA Ju, T Knowles, D Vigolo, Y Shen
(2025)
(doi: 10.1101/2025.06.03.657213)
Transcript Identification Using Arrayed Hydrogels with TrapFISH
DB Morse, Z Toprakcioglu, A Denduluri-Marthi, JD Brenton, CJ Thomas, TPJ Knowles
Advanced Materials Technologies
(2025)
(doi: 10.1002/admt.202401953)
Balancing Antigen Loading on Gold Nanoparticles: Implications for Future Cancer Vaccine Strategies
M Ghirardello, A Guerreiro, C Bretón, I Compañón, J Zabalza, V Mangini, JM Peregrina, GJL Bernardes, F Corzana
Chemistry (Weinheim an der Bergstrasse, Germany)
(2025)
(doi: 10.1002/chem.202501286)
Destabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core
H Nadwa, ZF Brotzakis, A Santucci, D Braconi, M Vendruscolo
(2025)
(doi: 10.1101/2025.05.27.656333)
Using a stable protein scaffold to display peptides that bind to alpha‐synuclein fibrils
S Bismut, MM Schneider, M Miyasaki, Y Feng, EJ Wilde, MD Gunawardena, TPJ Knowles, GS Kaminski Schierle, LS Itzhaki, JR Kumita
Protein science : a publication of the Protein Society
(2025)
34
(doi: 10.1002/pro.70150)
Development of potent humanized TNFα inhibitory nanobodies for therapeutic applications in TNFα-mediated diseases
T Yin, A Ramon, M Greenig, P Sormanni, L D’Adamio
mAbs
(2025)
17
(doi: 10.1080/19420862.2025.2498164)
High-throughput Screening of the Mechanical Properties of Peptide Assemblies
SK Yorke, Z Yang, A Levin, A Ray, JO Boamah, TPJ Knowles, MJ Buehler
(2025)
(doi: 10.48550/arxiv.2505.08850)
A mechanism for MEX-5-driven disassembly of PGL-3/RNA condensates in vitro
NS Lewis, S Zedlitz, H Ausserwöger, PM McCall, L Hubatsch, M Nousch, M Ruer-Gruß, C Hoege, F Jülicher, CR Eckmann, TPJ Knowles, AA Hyman
Proceedings of the National Academy of Sciences
(2025)
122
(doi: 10.1073/pnas.2412218122)
An Expanded View of RNA Modification with Carbohydrate-Based Metabolic Probes
ME Hazemi, MB Geeson, FM Müller, S Mikutis, AJ Enright, GJL Bernardes
Jacs Au
(2025)
5
(doi: 10.1021/jacsau.5c00249)
Tandem-repeat proteins introduce tuneable properties to engineered biomolecular condensates
TLC Ng, MP Hoare, MJ Maristany, EJ Wilde, T Sneideris, J Huertas, BK Agbetiameh, M Furukawa, JA Joseph, TPJ Knowles, R Collepardo-Guevara, LS Itzhaki, JR Kumita
Chemical Science
(2025)
16
(doi: 10.1039/d5sc00903k)
The thermodynamic hypothesis of protein aggregation
M Vendruscolo
Molecular aspects of medicine
(2025)
103
(doi: 10.1016/j.mam.2025.101364)
Prediction of Antibody Non-Specificity using Protein Language Models and Biophysical Parameters
LI Sakhnini, L Beltrame, S Fulle, P Sormanni, A Henriksen, N Lorenzen, M Vendruscolo, D Granata
(2025)
(doi: 10.1101/2025.04.28.650927)
A single fibril study reveals that ApoE inhibits the elongation of Aβ42 fibrils in an isoform-dependent manner.
S Dasadhikari, S Ghosh, S Pal, TPJ Knowles, K Garai
Communications Chemistry
(2025)
8
(doi: 10.1038/s42004-025-01524-z)
Rational Design of Single‐Domain Antibodies Targeting the Central Nervous System Neurite Outgrowth Inhibitor Nogo‐A
V Roy Chowdhury, A Röntgen, M Greenig, Y Méndez Gómez, SP Spiegel, M Nowinska, A Ramon, P Sormanni, A Chan, M Vendruscolo
Wiley Interdisciplinary Reviews: RNA
(2025)
4
(doi: 10.1002/appl.70012)
Aggregation of α-synuclein splice isoforms through a phase separation pathway
A Röntgen, Z Toprakcioglu, ST Dada, OM Morris, TPJ Knowles, M Vendruscolo
Science advances
(2025)
11
(doi: 10.1126/sciadv.adq5396)
Yusuf Hamied Department of Chemistry
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