Centre for Misfolding Diseases

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  • Currently displaying 461 - 480 of 2350 publications
Author(s)
Publication title
Journal Name
Publication year
Elongation rate and average length of amyloid fibrils in solution using isotope-labelled small-angle neutron scattering
BJ Eves, JJ Doutch, AE Terry, H Yin, M Moulin, M Haertlein, VT Forsyth, P Flagmeier, TPJ Knowles, DM Dias, G Lotze, AM Seddon, AM Squires
RSC Chemical Biology
(2021)
2
(doi: 10.1039/d1cb00001b)
Allosteric Antagonist Modulation of TRPV2 by Piperlongumine Impairs Glioblastoma Progression
J Conde, RA Pumroy, C Baker, T Rodrigues, A Guerreiro, BB Sousa, MC Marques, BP de Almeida, S Lee, EP Leites, D Picard, A Samanta, SH Vaz, F Sieglitz, M Langini, M Remke, R Roque, T Weiss, M Weller, Y Liu, S Han, F Corzana, VA Morais, CC Faria, T Carvalho, P Filippakopoulos, B Snijder, NL Barbosa-Morais, VY Moiseenkova-Bell, GJL Bernardes
ACS central science
(2021)
7
(doi: 10.1021/acscentsci.1c00070)
A mistranslation-prone transcriptome underlying polyglutamine expansion diseases
F Buhr, PS Ciryam, M Vendruscolo
Nat Rev Mol Cell Biol
(2021)
22
(doi: 10.1038/s41580-021-00368-4)
Tau AD fragment aggregates proliferate through autocatalytic secondary nucleation
DR Camargo, E Sileikis, S Chia, E Axell, K Bernfur, R Cataldi, S Cohen, G Meisl, J Habchi, T Knowles, M Vendruscolo, S Linse
(2021)
(doi: 10.21203/rs.3.rs-351489/v1)
Learning the molecular grammar of protein condensates from sequence determinants and embeddings.
KL Saar, AS Morgunov, R Qi, WE Arter, G Krainer, AA Lee, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2021)
118
(doi: 10.1073/pnas.2019053118)
The role of reversible and irreversible covalent chemistry in targeted protein degradation.
H Kiely-Collins, GE Winter, GJL Bernardes
Cell chemical biology
(2021)
28
(doi: 10.1016/j.chembiol.2021.03.005)
Scaling analysis reveals the mechanism and rates of prion replication in vivo.
G Meisl, T Kurt, I Condado-Morales, C Bett, S Sorce, M Nuvolone, TCT Michaels, D Heinzer, M Avar, SIA Cohen, S Hornemann, A Aguzzi, CM Dobson, CJ Sigurdson, TPJ Knowles
Nat Struct Mol Biol
(2021)
28
(doi: 10.1038/s41594-021-00565-x)
The role of clearance mechanisms in the kinetics of pathological protein aggregation involved in neurodegenerative diseases.
TB Thompson, G Meisl, TPJ Knowles, A Goriely
J Chem Phys
(2021)
154
(doi: 10.1063/5.0031650)
From Protein Building Blocks to Functional Materials
Y Shen, A Levin, A Kamada, Z Toprakcioglu, M Rodriguez-Garcia, Y Xu, TPJ Knowles
ACS nano
(2021)
15
(doi: 10.1021/acsnano.0c08510)
Shear-mediated sol-gel transition of regenerated silk allows the formation of Janus-like microgels.
Z Toprakcioglu, TPJ Knowles
Scientific Reports
(2021)
11
(doi: 10.1038/s41598-021-85199-1)
Comparative Studies in the A30P and A53T α-Synuclein C. elegans Strains to Investigate the Molecular Origins of Parkinson's Disease
M Perni, A van der Goot, R Limbocker, TJ van Ham, FA Aprile, CK Xu, P Flagmeier, K Thijssen, P Sormanni, G Fusco, SW Chen, PK Challa, JB Kirkegaard, RF Laine, KY Ma, MBD Müller, T Sinnige, JR Kumita, SIA Cohen, R Seinstra, GS Kaminski Schierle, CF Kaminski, D Barbut, A De Simone, TPJ Knowles, M Zasloff, EAA Nollen, M Vendruscolo, CM Dobson
Frontiers in cell and developmental biology
(2021)
9
(doi: 10.3389/fcell.2021.552549)
Precise protein conjugation technology for the construction of homogenous glycovaccines
A Kitowski, F Corzana, GJL Bernardes
Drug Discovery Today Technologies
(2021)
38
(doi: 10.1016/j.ddtec.2020.11.007)
Kinetic analysis reveals that independent nucleation events determine the progression of polyglutamine aggregation in C. elegans
T Sinnige, G Meisl, TCT Michaels, M Vendruscolo, TPJ Knowles, RI Morimoto
Proceedings of the National Academy of Sciences
(2021)
118
(doi: 10.1073/pnas.2021888118)
Fragment-based computational design of antibodies targeting structured epitopes
MA Rangel, A Bedwell, E Costanzi, R Taylor, R Russo, G Bernardes, S Ricagno, J Frydman, M Vendruscolo, P Sormanni
(2021)
(doi: 10.1101/2021.03.02.433360)
Rationally Designed Bicyclic Peptides Prevent the Conversion of Aβ42 Assemblies Into Fibrillar Structures.
T Ikenoue, FA Aprile, P Sormanni, M Vendruscolo
Frontiers in neuroscience
(2021)
15
(doi: 10.3389/fnins.2021.623097)
Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction
S Sieste, T Mack, E Lump, M Hayn, D Schütz, A Röcker, C Meier, K Kaygisiz, F Kirchhoff, TPJ Knowles, FS Ruggeri, CV Synatschke, J Münch, T Weil
Advanced Functional Materials
(2021)
31
(doi: 10.1002/adfm.202009382)
Reentrant liquid condensate phase of proteins is stabilized by hydrophobic and non-ionic interactions
G Krainer, TJ Welsh, JA Joseph, JR Espinosa, S Wittmann, E de Csilléry, A Sridhar, Z Toprakcioglu, G Gudiškytė, MA Czekalska, WE Arter, J Guillén-Boixet, TM Franzmann, S Qamar, PS George-Hyslop, AA Hyman, R Collepardo-Guevara, S Alberti, TPJ Knowles
Nature Communications
(2021)
12
(doi: 10.1038/s41467-021-21181-9)
Shear-Mediated Sol-Gel Transition of Regenerated Silk Allows the Formation of Janus-like Microgels
Z Toprakcioglu, T Knowles
(2021)
(doi: 10.26434/chemrxiv.13909250.v1)
Shear-Mediated Sol-Gel Transition of Regenerated Silk Allows the Formation of Janus-like Microgels
Z Toprakcioglu, T Knowles
(2021)
(doi: 10.26434/chemrxiv.13909250)
Quantifying misfolded protein oligomers as drug targets and biomarkers in Alzheimer and Parkinson diseases
K Kulenkampff, A-M Wolf Perez, P Sormanni, J Habchi, M Vendruscolo
Nature Reviews Chemistry
(2021)
5
(doi: 10.1038/s41570-021-00254-9)
Yusuf Hamied Department of Chemistry
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