Centre for Misfolding Diseases

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  • Currently displaying 541 - 560 of 2367 publications
Author(s)
Publication title
Journal Name
Publication year
Cholesterol-rich naked mole-rat brain lipid membranes are susceptible to amyloid beta-induced damage in vitro.
D Frankel, M Davies, B Bhushan, Y Kulaberoglu, P Urriola-Munoz, J Bertrand-Michel, MR Pergande, AA Smith, S Preet, TJ Park, M Vendruscolo, KS Rankin, SM Cologna, JR Kumita, N Cenac, E St John Smith
Aging
(2020)
12
(doi: 10.18632/aging.202138)
Small-molecule sequestration of amyloid-β as a drug discovery strategy for Alzheimer's disease
GT Heller, FA Aprile, TCT Michaels, R Limbocker, M Perni, FS Ruggeri, B Mannini, T Löhr, M Bonomi, C Camilloni, A De Simone, IC Felli, R Pierattelli, TPJ Knowles, CM Dobson, M Vendruscolo
Sci Adv
(2020)
6
(doi: 10.1126/sciadv.abb5924)
Pairs of amino acids at the P- and A-sites of the ribosome predictably and causally modulate translation-elongation rates.
N Ahmed, UA Friedrich, P Sormanni, P Ciryam, NS Altman, B Bukau, G Kramer, EP O'Brien
J Mol Biol
(2020)
432
(doi: 10.1016/j.jmb.2020.10.030)
The Hsc70 Disaggregation Machinery Removes Monomer Units Directly from α-Synuclein Fibril Ends
M Schneider, S Gautam, T Herling, E Andrzejewska, G Krainer, A Miller, Q Peter, FS Ruggeri, M Vendruscolo, A Bracher, C Dobson, U Hartl, T Knowles
(2020)
(doi: 10.1101/2020.11.02.365825)
meCLICK-Seq, a Substrate-Hijacking and RNA Degradation Strategy for the Study of RNA Methylation
S Mikutis, M Gu, E Sendinc, ME Hazemi, H Kiely-Collins, D Aspris, GS Vassiliou, Y Shi, K Tzelepis, GJL Bernardes
ACS Cent Sci
(2020)
6
(doi: 10.1021/acscentsci.0c01094)
Machine learning models for predicting protein condensate formation from sequence determinants and embeddings
K Saar, A Morgunov, R Qi, W Arter, G Krainer, A Lee, T Knowles
(2020)
(doi: 10.1101/2020.10.26.354753)
Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction
S Sieste, T Mack, E Lump, M Hayn, D Schütz, A Röcker, C Meier, F Kirchhoff, T Knowles, FS Ruggeri, C Synatschke, J Münch, T Weil
(2020)
(doi: 10.26434/chemrxiv.13129709)
Supramolecular Peptide Nanofibrils with Optimized Sequences and Molecular Structures for Efficient Retroviral Transduction
S Sieste, T Mack, E Lump, M Hayn, D Schütz, A Röcker, C Meier, F Kirchhoff, T Knowles, FS Ruggeri, C Synatschke, J Münch, T Weil
(2020)
(doi: 10.26434/chemrxiv.13129709.v1)
Microscale diffusiophoresis of proteins
Q Peter, R Jacquat, T Herling, P Challa, T Kartanas, T Knowles
(2020)
(doi: 10.21203/rs.3.rs-90645/v1)
Rapid structural, kinetic, and immunochemical analysis of alpha-synuclein oligomers in solution
WE Arter, CK Xu, M Castellana-Cruz, TW Herling, G Krainer, KL Saar, JR Kumita, CM Dobson, TPJ Knowles
Nano Letters
(2020)
20
(doi: 10.1021/acs.nanolett.0c03260)
An intrinsically disordered motif regulates the interaction between the p47 adaptor and the p97 AAA+ ATPase.
AE Conicella, R Huang, ZA Ripstein, A Nguyen, E Wang, T Löhr, P Schuck, M Vendruscolo, JL Rubinstein, LE Kay
Proceedings of the National Academy of Sciences
(2020)
117
(doi: 10.1073/pnas.2013920117)
Mechanistic insights into transition metal-mediated bioorthogonal uncaging reactions.
E Latocheski, GM Dal Forno, TM Ferreira, BL Oliveira, GJL Bernardes, JB Domingos
Chem Soc Rev
(2020)
49
(doi: 10.1039/d0cs00630k)
Serine-Selective Bioconjugation.
JC Vantourout, SR Adusumalli, KW Knouse, DT Flood, A Ramirez, NM Padial, A Istrate, K Maziarz, JN deGruyter, RR Merchant, JX Qiao, MA Schmidt, MJ Deery, MD Eastgate, PE Dawson, GJL Bernardes, PS Baran
J Am Chem Soc
(2020)
142
(doi: 10.1021/jacs.0c05595)
The role of fibril structure and surface hydrophobicity in secondary nucleation of amyloid fibrils
D Thacker, K Sanagavarapu, B Frohm, G Meisl, TPJ Knowles, S Linse
Proc Natl Acad Sci U S A
(2020)
117
(doi: 10.1073/pnas.2002956117)
The role of clearance mechanisms in the kinetics of toxic protein aggregates involved in neurodegenerative diseases
TB Thompson, G Meisl, T Knowles, A Goriely
(2020)
(doi: 10.48550/arxiv.2009.14135)
Kinetic fingerprints differentiate the mechanisms of action of anti-Aβ antibodies.
S Linse, T Scheidt, K Bernfur, M Vendruscolo, CM Dobson, SIA Cohen, E Sileikis, M Lundqvist, F Qian, T O'Malley, T Bussiere, PH Weinreb, CK Xu, G Meisl, SRA Devenish, TPJ Knowles, O Hansson
Nature Structural and Molecular Biology
(2020)
27
(doi: 10.1038/s41594-020-0505-6)
Deformable and robust core-shell protein microcapsules templated by liquid-liquid phase separated microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez-Garcia, D Klenerman, TPJ Knowles
(2020)
(doi: 10.48550/arxiv.2009.13413)
Sequential dual site-selective protein labelling enabled by lysine modification.
MJ Matos, L Brown, B Bernardim, A Guerreiro, G Jiménez-Osés, GJL Bernardes
Bioorganic & Medicinal Chemistry
(2020)
28
(doi: 10.1016/j.bmc.2020.115783)
Microfluidic Affinity Profiling reveals a Broad Range of Target Affinities for Anti-SARS-CoV-2 Antibodies in Plasma of Covid Survivors
M Schneider, M Emmenegger, C Xu, IC Morales, G Meisl, P Turelli, C Zografou, M Zimmermann, B Frey, S Fiedler, V Denninger, R Jacquat, L Madrigal, A Ilsley, V Kosmoliaptsis, H Fiegler, D Trono, T Knowles, A Aguzzi
medRxiv
(2020)
(doi: 10.1101/2020.09.20.20196907)
Converting lateral scanning into axial focusing to speed up three-dimensional microscopy.
T Chakraborty, B Chen, S Daetwyler, B-J Chang, O Vanderpoorten, E Sapoznik, CF Kaminski, TPJ Knowles, KM Dean, R Fiolka
Light: Science & Applications
(2020)
9
(doi: 10.1038/s41377-020-00401-9)
Yusuf Hamied Department of Chemistry
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