Centre for Misfolding Diseases

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  • Currently displaying 421 - 440 of 2350 publications
Author(s)
Publication title
Journal Name
Publication year
Combating small-molecule aggregation with machine learning
K Lee, A Yang, YC Lin, D Reker, GJL Bernardes, T Rodrigues
Cell Reports Physical Science
(2021)
2
(doi: 10.1016/j.xcrp.2021.100573)
Deformable and Robust Core–Shell Protein Microcapsules Templated by Liquid–Liquid Phase-Separated Microdroplets
Y Xu, Y Shen, TCT Michaels, KN Baumann, D Vigolo, Q Peter, Y Lu, KL Saar, D Vella, H Zhu, B Li, H Yang, APM Guttenplan, M Rodriguez-Garcia, D Klenerman, TPJ Knowles
Advanced Materials Interfaces
(2021)
8
(doi: 10.1002/admi.202101071)
The binding of the small heat-shock protein αB-crystallin to fibrils of α-synuclein is driven by entropic forces
T Scheidt, JA Carozza, CC Kolbe, FA Aprile, O Tkachenko, MMJ Bellaiche, G Meisl, QAE Peter, TW Herling, S Ness, M Castellana-Cruz, JLP Benesch, M Vendruscolo, CM Dobson, P Arosio, TPJ Knowles
Proceedings of the National Academy of Sciences of the United States of America
(2021)
118
(doi: 10.1073/pnas.2108790118|1of8)
New Frontiers for Machine Learning in Protein Science.
AS Morgunov, KL Saar, M Vendruscolo, TPJ Knowles
Journal of Molecular Biology
(2021)
433
(doi: 10.1016/j.jmb.2021.167232)
Assessment of Therapeutic AntibodyDevelopability by Combinations of In Vitro and In Silico Methods
A-M Wolf Pérez, N Lorenzen, M Vendruscolo, P Sormanni
Methods in Molecular Biology
(2021)
2313
(doi: 10.1007/978-1-0716-1450-1_4)
The Amyloid-β Pathway in Alzheimer's Disease
H Hampel, J Hardy, K Blennow, C Chen, G Perry, SH Kim, VL Villemagne, P Aisen, M Vendruscolo, T Iwatsubo, CL Masters, M Cho, L Lannfelt, JL Cummings, A Vergallo
Mol Psychiatry
(2021)
26
(doi: 10.1038/s41380-021-01249-0)
Unraveling the Physicochemical Determinants of Protein Liquid-liquid Phase Separation by Nanoscale Infrared Vibrational Spectroscopy
FS Ruggeri, AM Miller, M Vendruscolo, TPJ Knowles
Bio Protocol
(2021)
11
(doi: 10.21769/bioprotoc.4122)
Liquid–Liquid Phase‐Separated Systems from Reversible Gel–Sol Transition of Protein Microgels (Adv. Mater. 33/2021)
Y Xu, R Qi, H Zhu, B Li, Y Shen, G Krainer, D Klenerman, TPJ Knowles
Advanced Materials
(2021)
33
(doi: 10.1002/adma.202170258)
Quantitative Measurement of the Affinity of Toxic and Nontoxic Misfolded Protein Oligomers for Lipid Bilayers and of its Modulation by Lipid Composition and Trodusquemine
S Errico, H Ramshini, C Capitini, C Canale, M Spaziano, D Barbut, M Calamai, M Zasloff, R Oropesa-Nuñez, M Vendruscolo, F Chiti
ACS chemical neuroscience
(2021)
12
(doi: 10.1021/acschemneuro.1c00327)
Sequence Determinants of the Aggregation of Proteins Within Condensates Generated by Liquid-liquid Phase Separation
M Vendruscolo, M Fuxreiter
Journal of molecular biology
(2021)
434
(doi: 10.1016/j.jmb.2021.167201)
Conformational Expansion of Tau in Condensates Promotes Irreversible Aggregation
J Wen, L Hong, G Krainer, Q-Q Yao, TPJ Knowles, S Wu, S Perrett
J Am Chem Soc
(2021)
143
(doi: 10.1021/jacs.1c03078)
Feedback control of protein aggregation
AJ Dear, TCT Michaels, TPJ Knowles, L Mahadevan
The Journal of chemical physics
(2021)
155
(doi: 10.1063/5.0055925)
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation
EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, J Lim, D Aspris, E Sendinc, DA Garyfallos, M Gu, R Ali, A Gutierrez, S Mikutis, GJL Bernardes, ES Fischer, A Bradley, GS Vassiliou, FJ Slack, K Tzelepis, RI Gregory
Mol Cell
(2021)
81
(doi: 10.1016/j.molcel.2021.06.031)
Mutations in two SARS-CoV-2 variants of concern reflect two distinct strategies of antibody escape
S Fiedler, V Denninger, A Morgunov, A Ilsley, R Worth, G Meisl, C Xu, M Piziorska, F Ricci, A Malik, S Devenish, M Schneider, V Kosmoliaptsis, A Aguzzi, A Iwasaki, H Fiegler, T Knowles
(2021)
(doi: 10.1101/2021.07.23.453327)
LAG3 is not expressed in human and murine neurons and does not modulate α-synucleinopathies.
M Emmenegger, E De Cecco, M Hruska-Plochan, T Eninger, MM Schneider, M Barth, E Tantardini, P de Rossi, M Bacioglu, RG Langston, A Kaganovich, N Bengoa-Vergniory, A Gonzalez-Guerra, M Avar, D Heinzer, R Reimann, LM Häsler, TW Herling, NS Matharu, N Landeck, K Luk, R Melki, PJ Kahle, S Hornemann, TPJ Knowles, MR Cookson, M Polymenidou, M Jucker, A Aguzzi
EMBO Mol Med
(2021)
13
(doi: 10.15252/emmm.202114745)
Understanding the role of memory re-activation and cross-reactivity in the defense against SARS-CoV-2
V Denninger, C Xu, G Meisl, A Morgunov, S Fiedler, A Ilsley, M Emmenegger, A Malik, M Piziorska, M Schneider, S Devenish, V Kosmoliaptsis, A Aguzzi, H Fiegler, T Knowles
(2021)
(doi: 10.1101/2021.07.23.453352)
Cytosolic aggregation of mitochondrial proteins disrupts cellular homeostasis by stimulating the aggregation of other proteins.
U Nowicka, P Chroscicki, K Stroobants, M Sladowska, M Turek, B Uszczynska-Ratajczak, R Kundra, T Goral, M Perni, CM Dobson, M Vendruscolo, A Chacinska
eLife
(2021)
10
(doi: 10.7554/eLife.65484)
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5‑LOX Inhibitor that Limits Inflammation
K Neukirch, K Alsabil, C-P Dinh, R Bilancia, M Raasch, A Ville, I Cerqua, G Viault, D Bréard, S Pace, V Temml, E Brunner, PM Jordan, MC Marques, K Loeser, A Gollowitzer, S Permann, J Gerstmeier, S Lorkowski, H Stuppner, U Garscha, T Rodrigues, GJL Bernardes, D Schuster, D Séraphin, P Richomme, A Rossi, AS Mosig, F Roviezzo, O Werz, J-J Helesbeux, A Koeberle
Journal of Medicinal Chemistry
(2021)
64
(doi: 10.1021/acs.jmedchem.1c00806)
Arylethynyltrifluoroborate Dienophiles for on Demand Activation of IEDDA Reactions
Z Zawada, Z Guo, BL Oliveira, CD Navo, H Li, PMSD Cal, F Corzana, G Jiménez-Osés, GJL Bernardes
Bioconjug Chem
(2021)
32
(doi: 10.1021/acs.bioconjchem.1c00276)
Modulation of the Interactions Between α-Synuclein and Lipid Membranes by Post-translational Modifications.
R Bell, M Vendruscolo
Frontiers in neurology
(2021)
12
(doi: 10.3389/fneur.2021.661117)
Yusuf Hamied Department of Chemistry
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